Welcome!

IBM Cloud Authors: Pat Romanski, Liz McMillan, David H Deans, Sematext Blog, Elizabeth White

News Feed Item

Top Ten Companies in DNA Sequencing

NEW YORK, Oct. 17, 2012 /PRNewswire/ -- Reportlinker.com announces that a new market research report is available in its catalogue:

 

Top Ten Companies in DNA Sequencing

http://www.reportlinker.com/p01013573/Top-Ten-Companies-in-DNA-Sequencin...

 

INTRODUCTION

 

The story of molecular biology is being both written and printed by sequencing tools—various chapters being currently authored by oncologists, ID experts, pathologists, and so forth. The narrative is understood by only those select few who have the cross discipline knowledge to comprehend what the sequencing tools output, and who also have the niche domain experience to act upon knowledge of that data. Recently, this story has begun to change as low cost next generation sequencing democratizes genome data, allowing a politics and commerce of inclusion, to enter the lab and now also the clinic.

 

Diagnostic manufacturers can now afford to develop sequencing tools as diagnostic shortcuts. The clinician does not need to understand the mathematical underpinnings of 16SrRNA coverage for phylogeny to run a rapid anthrax test.

 

Tandem repeats and retrotransposons have been conveniently converted into a "plus" or "minus" sign—a red light/green light clinical decision.

 

When Watson and Crick let the genie out of the research bottle, it was inevitable that this day would arrive—the only question was when it would happen. The types of automation that enabled cost efficiencies in sequencing tools have become decision tree shortcuts in the clinic, whereupon the first tangible fruits from the promise of personalized medicine have become apparent.

 

DNA sequencing is a strategic genomics tool that allows us to study how the genome varies among individuals and how that variation correlates to disease. Sequencing technologies are a critical part of today's life-science industry, affecting a wide range of activity from drug discovery to diagnostics. This focused document profiles the top 10 companies of the industry and explores the underlying technologies driving the industry's growth. Each technology is analyzed to determine its market status, impact on future market segments, and future growth potential. It should be noted that sequencing costs may only contribute 10% to 20% of a typical biomedical projects overall costs.

 

Of significance is the large occurrence of collaboration and co-ownership among the top players. Certain individuals, such as Mike Hunkapller and George Church, appear and reappear in several of the leading companies as co-founder, adviser or board member. But investment in seemingly rival efforts is also unusually high, underscoring both the connected nature of the research and commercial community, and also a "quantitative easing" or de-risking of being on the right team when the eventual winners are crowned in this high stakes field.

For this top 10 report, many factors were considered when selecting the companies. In general, chosen companies have a solid foundation built around their sequencing technology and have done an excellent job strategically positioning themselves into one (or many) of the facets of the industry.

 

In a reply to BCC from one of the top sequencing industry leaders, George Church explains in more detail some of the technological specifics to success. Next generation sequencing (NGS) systems are evolving rapidly, meaning this should be a core area of focus for a company should they want to excel now and in the near future.

 

Of the NGS systems, benchtop sequencers have a good niche currently. Although they can't process as much as the larger high-throughput systems, being smaller has its obvious advantages. In the long term, benchtop sequencers may end up getting squeezed out of their niche however, finding no room for successful commercialization between the large high-throughput systems and handheld or portable sequencers which are based around nanopore technology.

 

At this stage there are several different approaches different companies are working on concerning nanopore-based technologies. Leading the way in this sector of sequencing will certainly help strengthen any company and their competitive position. Many companies are competing, and to a certain extent this is a race of scaling, that is, who can get the most nanopores into the smallest area.

 

One of the problems that arise from the sequencing process is the flood of data that results. A key issue to note is just how well informatics will be able to handle this data flood. As read lengths become longer and more accurate, the informatics becomes easier. Interpretation of the data is another issue that arises, but focusing on medically actionable determinations should simplify rather than complicate the interpretation of results.

 

Another point to consider is whole genome sequencing, a goal for many. Applications from this process becoming available everywhere at low cost aren't too far into the future at the moment. One application has already emerged, a test for 2,400 highly predictive medical genetic diseases. This is superior to exome testing as these have the serious flaw of missing phasing information. For example, if a genome has mutations on say exon number 2 and exon number 7 of a gene, the exome doesn't distinguish between two hits in one gene copy (the other copy is fine) vs. hits in both copies (no healthy copies).

 

Given these criteria to success, along with other factors which BCC chose to examine, BCC has selected these 10 companies for this report that we feel are deserving of recognition and are leaders in their industry, This list includes:

 

Agilent Technologies Inc.

Genia

International Business Machines Corp.

Illumina Inc.

Knome Inc.

Life Technologies

Oxford Nanopore Technologies

Pacific Biosciences

Raindance Technologies Inc.

Roche Holding AG.

 

As any top 10 list is invariably subjective, there are also several companies profiled in less detail. These companies were on the bubble, or should be watched in the near future.

 

STUDY GOALS AND OBJECTIVES

 

This document is a specialty report related to the BCC Research report BIO045D authored by John Bergin. The goal of this document is to provide a more in-depth look at the top tier DNA sequencing companies as well as some of the second tier companies to look for in the near future, and to note the technological changes within the DNA sequencing industry that are sure to play a role in the years to come.

 

More specifically, the objectives include identifying companies that are considered the leaders in their field and the technological means these companies are using to exploit their markets and dominate their field. Key technology points explored include:

 

How the NGS (next generation sequencing) benchtop systems will do versus the larger, high throughput systems.

How well NGS systems will penetrate into diagnostics.

Which up and coming nanopore-based technologies will emerge and how will this affect market applications.

How well will sequencing informatics be able to solve the data flood.

When will mass whole genome sequencing applications emerge.

 

Other major factors used to determine top companies in the field include:

 

Alliance, merger, and acquisition strategy.

Financing.

Intellectual property (patent) portfolio.

 

INTENDED AUDIENCE

 

This study will be of particular interest to life-science research tools suppliers, pharmaceutical, diagnostics, nanotechnology, bioinformatics, semiconductor, and biotechnology companies. It will also be valuable to companies involved in genome sequencing projects, sequencing centers, manufacturers of microarrays, suppliers of molecular diagnostics assays, bioinformatics companies, and cancer researchers and clinicians. As this report is a profiling of top companies in the DNA sequencing field, the main audience should also include executive management personnel and marketing and financial analysts.

 

SCOPE

 

The scope of this report is focused on a select 10 companies in DNA sequencing, and the key areas in the field that are driving industry growth allowing these companies to succeed. These areas include Sanger, next-generation, and emerging sequencing technologies; the markets for sample preparation products, sequencing instruments and consumables; and bioinformatics and sequencing services. A key area BCC also explores is industry structure, noting strategic alliances and acquisitions along with pertinent patent information.

 

METHODOLOGY

 

Based on primary and secondary market analysis, this report analyzes the top 10 companies in DNA sequencing as well as some additional companies worth recognizing.

 

 

 

TABLE OF CONTENTS

 

CHAPTER 1 INTRODUCTION 1

STUDY GOALS AND OBJECTIVES 2

INTENDED AUDIENCE 3

SCOPE 3

METHODOLOGY 3

RELATED BCC REPORTS 3

BCC ONLINE SERVICES 4

DISCLAIMER 4

CHAPTER 2 DNA SEQUENCING TECHNOLOGY OVERVIEW 6

HISTORY 6

COST BREAKDOWN 7

CURRENT TECHNOLOGY OVERVIEW 7

TABLE 1 LIFE CYCLE OF DNA SEQUENCING TECHNOLOGIES 7

SANGER SEQUENCING 8

NEXT GENERATION SEQUENCING (NGS) 8

EMERGING SEQUENCING 8

TABLE 2 SEQUENCING INSTRUMENT COMPETITORS BY TECHNOLOGY 9

SANGER SEQUENCING 9

NEXT GENERATION SEQUENCING 10

NEXT GENERATION APPLICATIONS PARTIALLY ENABLED BY LOWER COSTS 10

NGS INSTRUMENT MARKET 11

TABLE 3 NGS INSTRUMENT MARKET SHARE IN 2011 ($ MILLIONS/%) 11

EMERGING SEQUENCING TECHNOLOGIES 12

TABLE 4 EMERGING SEQUENCING TECHNOLOGIES 12

TABLE 5 TOP COMPANIES IN EMERGING SEQUENCING INDUSTRY 13

BENCHTOP SEQUENCERS 13

TABLE 6 BENCHTOP SEQUENCING TECHNOLOGIES 13

SAMPLE PREPARATION REAGENTS AND KITS 13

TABLE 7 SEQUENCING SAMPLE PREPARATION COMPANY POSITIONING 14

SEQUENCE CAPTURE INDUSTRY 14

BIOINFORMATICS TECHNOLOGIES 14

TABLE 8 NGS SEQUENCING BIOINFORMATICS WORKFLOW 15

SEQUENCING SERVICES 16

CHAPTER 3 MARKET SUMMARY 18

MARKET GROWTH 18

TABLE 9 DNA SEQUENCING KEY GROWTH DRIVING FORCES 18

OVERALL MARKET 19

TABLE 10 GLOBAL VALUE OF SEQUENCING PRODUCTS AND SERVICES BY TYPE, THROUGH

2016 ($ MILLIONS) 19

INSTRUMENTS AND CONSUMABLES 19

TABLE 11 GLOBAL VALUE OF THE SEQUENCING INSTRUMENTS AND CONSUMABLES

MARKET BY PRODUCT TYPE, THROUGH 2016 ($ MILLIONS) 19

INSTRUMENTS 20

TABLE 12 GLOBAL VALUE OF SEQUENCING INSTRUMENTS BY PLATFORM, THROUGH 2016

($ MILLIONS) 20

CONSUMABLES 20

SEQUENCING SERVICES 21

TABLE 13 GLOBAL VALUE OF SEQUENCING SERVICES BY END-USER MARKET, THROUGH

2016 ($ MILLIONS) 21

CLINICAL DIAGNOSTICS 21

R&D, PHARMA, BIOTECH 22

WORKFLOW PRODUCTS 22

SAMPLE PREP 22

BIOINFORMATICS 23

GLOBAL SEQUENCING MARKET BROKEN DOWN BY REGION 23

CHAPTER 4 SEQUENCING PATENT ANALYSIS 26

FIGURE 1 SEQUENCING PATENTS, 2001–2011 (NO. OF PATENTS) 26

FIGURE 2 SEQUENCING PATENTS BY REGION, 2001–2011 (NO. OF PATENTS) 27

FIGURE 3 EMERGING SEQUENCING COMPANY PATENTS BY REGION 28

CHAPTER 5 THE TOP 10 COMPANIES IN DNA SEQUENCING 31

AGILENT TECHNOLOGIES INC. 31

STRATEGIC ALLIANCES 32

FINANCIALS 33

KEY MANAGEMENT 33

GENIA 33

TABLE 14 COMMERCIAL SEQUENCER COMPETITIVE POSITIONING 34

TECHNOLOGY 34

KEY MANAGEMENT 35

INTERNATIONAL BUSINESS MACHINES CORP. 35

KEY MANAGEMENT 37

ILLUMINA, INC. 37

ALLIANCES, MERGERS, AND ACQUISITIONS 38

ILLUMINA AND NGS 39

TABLE 15 ILLUMINA SEQUENCING PORTFOLIO BY INSTRUMENT ($ PER YEAR) 39

KEY MANAGEMENT 40

KNOME INC. 40

TABLE 16 KNOME'S BREAKDOWN OF VARIANTS 41

STRATEGIC ALLIANCES 41

KEY MANAGEMENT 42

LIFE TECHNOLOGIES INC. 42

ION TORRENT TECHNOLOGY 44

SANGER SEQUENCING 44

TABLE 17 LIFE TECHNOLOGIES' 3500DX INSTRUMENTS 45

NGS 45

TABLE 18 5500 SERIES GENETIC ANALYSIS SYSTEMS SPECIFICATIONS 45

THIRD GENERATION SEQUENCING 46

KEY ACQUISITIONS 46

MANAGEMENT 47

OXFORD NANOPORE TECHNOLOGIES 47

FINANCE HISTORY 48

TECHNOLOGY 48

KEY MANAGEMENT 49

PACIFIC BIOSCIENCES 49

ALLIANCES 51

Gen-Probe 51

Cycle Computing 51

LI-COR 51

Others 51

FINANCIALS 52

INITIAL PUBLIC OFFERING 52

EMPLOYEES AND LAYOFFS 52

INTELLECTUAL PROPERTY 52

MANAGEMENT 53

RAINDANCE TECHNOLOGIES INC. 53

TECHNOLOGY 53

SEQUENCE CAPTURE PANELS 54

TABLE 19 RAINDANCE RESEARCH SCREENING PANELS 54

STRATEGIC ALLIANCES 55

TABLE 20 RAINDANCE STRATEGIC ALLIANCES 55

RECENT FINANCES 56

MANAGEMENT 56

ROCHE HOLDING AG 57

TABLE 21 ROCHE DIAGNOSTICS SALES, BY REGION 2011 (%) 57

TABLE 22 ROCHE 454 SEQUENCING SYSTEMS COMPARISON 58

NIMBLEGEN 58

FLUIDIGM 59

IBM 59

MANAGEMENT 60

OTHER COMPANIES TO WATCH 60

BGI 60

COMPLETE GENOMICS INC. 61

DANAHER 62

FLUIDIGM CORPORATION 62

GEN-PROBE INC. 63

HELICOS BIOSCIENCES CORPORATION 63

NUGEN TECHNOLOGIES INC. 64

 

LIST OF TABLES

TABLE 1 LIFE CYCLE OF DNA SEQUENCING TECHNOLOGIES 7

TABLE 2 SEQUENCING INSTRUMENT COMPETITORS BY TECHNOLOGY 9

TABLE 3 NGS INSTRUMENT MARKET SHARE IN 2011 ($ MILLIONS/%) 11

TABLE 4 EMERGING SEQUENCING TECHNOLOGIES 12

TABLE 5 TOP COMPANIES IN EMERGING SEQUENCING INDUSTRY 13

TABLE 6 BENCHTOP SEQUENCING TECHNOLOGIES 13

TABLE 7 SEQUENCING SAMPLE PREPARATION COMPANY POSITIONING 14

TABLE 8 NGS SEQUENCING BIOINFORMATICS WORKFLOW 15

TABLE 9 DNA SEQUENCING KEY GROWTH DRIVING FORCES 18

TABLE 10 GLOBAL VALUE OF SEQUENCING PRODUCTS AND SERVICES BY TYPE, THROUGH

2016 ($ MILLIONS) 19

TABLE 11 GLOBAL VALUE OF THE SEQUENCING INSTRUMENTS AND CONSUMABLES

MARKET BY PRODUCT TYPE, THROUGH 2016 ($ MILLIONS) 19

TABLE 12 GLOBAL VALUE OF SEQUENCING INSTRUMENTS BY PLATFORM, THROUGH 2016

($ MILLIONS) 20

TABLE 13 GLOBAL VALUE OF SEQUENCING SERVICES BY END-USER MARKET, THROUGH

2016 ($ MILLIONS) 21

TABLE 14 COMMERCIAL SEQUENCER COMPETITIVE POSITIONING 34

TABLE 15 ILLUMINA SEQUENCING PORTFOLIO BY INSTRUMENT ($ PER YEAR) 39

TABLE 16 KNOME'S BREAKDOWN OF VARIANTS 41

TABLE 17 LIFE TECHNOLOGIES' 3500DX INSTRUMENTS 45

TABLE 18 5500 SERIES GENETIC ANALYSIS SYSTEMS SPECIFICATIONS 45

TABLE 19 RAINDANCE RESEARCH SCREENING PANELS 54

TABLE 20 RAINDANCE STRATEGIC ALLIANCES 55

TABLE 21 ROCHE DIAGNOSTICS SALES, BY REGION 2011 (%) 57

TABLE 22 ROCHE 454 SEQUENCING SYSTEMS COMPARISON 58

 

LIST OF FIGURES

FIGURE 1 SEQUENCING PATENTS, 2001–2011 (NO. OF PATENTS) 26

FIGURE 2 SEQUENCING PATENTS BY REGION, 2001–2011 (NO. OF PATENTS) 27

FIGURE 3 EMERGING SEQUENCING COMPANY PATENTS BY REGION 28

 

 

 

To order this report:

Genomics Industry: Top Ten Companies in DNA Sequencing

 

Nicolas Bombourg
Reportlinker
Email: nicolasbombourg@reportlinker.com
US: (805)652-2626
Intl: +1 805-652-2626

 

SOURCE Reportlinker

More Stories By PR Newswire

Copyright © 2007 PR Newswire. All rights reserved. Republication or redistribution of PRNewswire content is expressly prohibited without the prior written consent of PRNewswire. PRNewswire shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon.

@ThingsExpo Stories
Identity is in everything and customers are looking to their providers to ensure the security of their identities, transactions and data. With the increased reliance on cloud-based services, service providers must build security and trust into their offerings, adding value to customers and improving the user experience. Making identity, security and privacy easy for customers provides a unique advantage over the competition.
SYS-CON Events announced today that 910Telecom will exhibit at the 19th International Cloud Expo, which will take place on November 1–3, 2016, at the Santa Clara Convention Center in Santa Clara, CA. Housed in the classic Denver Gas & Electric Building, 910 15th St., 910Telecom is a carrier-neutral telecom hotel located in the heart of Denver. Adjacent to CenturyLink, AT&T, and Denver Main, 910Telecom offers connectivity to all major carriers, Internet service providers, Internet backbones and ...
SYS-CON Events announced today that Pulzze Systems will exhibit at the 19th International Cloud Expo, which will take place on November 1–3, 2016, at the Santa Clara Convention Center in Santa Clara, CA. Pulzze Systems, Inc. provides infrastructure products for the Internet of Things to enable any connected device and system to carry out matched operations without programming. For more information, visit http://www.pulzzesystems.com.
There is growing need for data-driven applications and the need for digital platforms to build these apps. In his session at 19th Cloud Expo, Muddu Sudhakar, VP and GM of Security & IoT at Splunk, will cover different PaaS solutions and Big Data platforms that are available to build applications. In addition, AI and machine learning are creating new requirements that developers need in the building of next-gen apps. The next-generation digital platforms have some of the past platform needs a...
Data is an unusual currency; it is not restricted by the same transactional limitations as money or people. In fact, the more that you leverage your data across multiple business use cases, the more valuable it becomes to the organization. And the same can be said about the organization’s analytics. In his session at 19th Cloud Expo, Bill Schmarzo, CTO for the Big Data Practice at EMC, will introduce a methodology for capturing, enriching and sharing data (and analytics) across the organizati...
Internet of @ThingsExpo, taking place November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA, is co-located with 19th Cloud Expo and will feature technical sessions from a rock star conference faculty and the leading industry players in the world. The Internet of Things (IoT) is the most profound change in personal and enterprise IT since the creation of the Worldwide Web more than 20 years ago. All major researchers estimate there will be tens of billions devices - comp...
SYS-CON Events announced today Telecom Reseller has been named “Media Sponsor” of SYS-CON's 19th International Cloud Expo, which will take place on November 1–3, 2016, at the Santa Clara Convention Center in Santa Clara, CA. Telecom Reseller reports on Unified Communications, UCaaS, BPaaS for enterprise and SMBs. They report extensively on both customer premises based solutions such as IP-PBX as well as cloud based and hosted platforms.
SYS-CON Events announced today that Adobe has been named “Bronze Sponsor” of SYS-CON's 18th Cloud Expo, which will take place on June 7-9, 2016, at the Javits Center in New York, New York. Adobe is changing the world though digital experiences. Adobe helps customers develop and deliver high-impact experiences that differentiate brands, build loyalty, and drive revenue across every screen, including smartphones, computers, tablets and TVs. Adobe content solutions are used daily by millions of co...
Why do your mobile transformations need to happen today? Mobile is the strategy that enterprise transformation centers on to drive customer engagement. In his general session at @ThingsExpo, Roger Woods, Director, Mobile Product & Strategy – Adobe Marketing Cloud, covered key IoT and mobile trends that are forcing mobile transformation, key components of a solid mobile strategy and explored how brands are effectively driving mobile change throughout the enterprise.
Pulzze Systems was happy to participate in such a premier event and thankful to be receiving the winning investment and global network support from G-Startup Worldwide. It is an exciting time for Pulzze to showcase the effectiveness of innovative technologies and enable them to make the world smarter and better. The reputable contest is held to identify promising startups around the globe that are assured to change the world through their innovative products and disruptive technologies. There w...
Data is the fuel that drives the machine learning algorithmic engines and ultimately provides the business value. In his session at Cloud Expo, Ed Featherston, a director and senior enterprise architect at Collaborative Consulting, will discuss the key considerations around quality, volume, timeliness, and pedigree that must be dealt with in order to properly fuel that engine.
19th Cloud Expo, taking place November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA, will feature technical sessions from a rock star conference faculty and the leading industry players in the world. Cloud computing is now being embraced by a majority of enterprises of all sizes. Yesterday's debate about public vs. private has transformed into the reality of hybrid cloud: a recent survey shows that 74% of enterprises have a hybrid cloud strategy. Meanwhile, 94% of enterpri...
Almost two-thirds of companies either have or soon will have IoT as the backbone of their business in 2016. However, IoT is far more complex than most firms expected. How can you not get trapped in the pitfalls? In his session at @ThingsExpo, Tony Shan, a renowned visionary and thought leader, will introduce a holistic method of IoTification, which is the process of IoTifying the existing technology and business models to adopt and leverage IoT. He will drill down to the components in this fra...
With so much going on in this space you could be forgiven for thinking you were always working with yesterday’s technologies. So much change, so quickly. What do you do if you have to build a solution from the ground up that is expected to live in the field for at least 5-10 years? This is the challenge we faced when we looked to refresh our existing 10-year-old custom hardware stack to measure the fullness of trash cans and compactors.
The emerging Internet of Everything creates tremendous new opportunities for customer engagement and business model innovation. However, enterprises must overcome a number of critical challenges to bring these new solutions to market. In his session at @ThingsExpo, Michael Martin, CTO/CIO at nfrastructure, outlined these key challenges and recommended approaches for overcoming them to achieve speed and agility in the design, development and implementation of Internet of Everything solutions wi...
Cloud computing is being adopted in one form or another by 94% of enterprises today. Tens of billions of new devices are being connected to The Internet of Things. And Big Data is driving this bus. An exponential increase is expected in the amount of information being processed, managed, analyzed, and acted upon by enterprise IT. This amazing is not part of some distant future - it is happening today. One report shows a 650% increase in enterprise data by 2020. Other estimates are even higher....
Today we can collect lots and lots of performance data. We build beautiful dashboards and even have fancy query languages to access and transform the data. Still performance data is a secret language only a couple of people understand. The more business becomes digital the more stakeholders are interested in this data including how it relates to business. Some of these people have never used a monitoring tool before. They have a question on their mind like “How is my application doing” but no id...
Smart Cities are here to stay, but for their promise to be delivered, the data they produce must not be put in new siloes. In his session at @ThingsExpo, Mathias Herberts, Co-founder and CTO of Cityzen Data, will deep dive into best practices that will ensure a successful smart city journey.
DevOps at Cloud Expo, taking place Nov 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA, is co-located with 19th Cloud Expo and will feature technical sessions from a rock star conference faculty and the leading industry players in the world. The widespread success of cloud computing is driving the DevOps revolution in enterprise IT. Now as never before, development teams must communicate and collaborate in a dynamic, 24/7/365 environment. There is no time to wait for long dev...
The 19th International Cloud Expo has announced that its Call for Papers is open. Cloud Expo, to be held November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA, brings together Cloud Computing, Big Data, Internet of Things, DevOps, Digital Transformation, Microservices and WebRTC to one location. With cloud computing driving a higher percentage of enterprise IT budgets every year, it becomes increasingly important to plant your flag in this fast-expanding business opportuni...