Welcome!

IBM Cloud Authors: Elizabeth White, Anders Wallgren, Pat Romanski, Flint Brenton, Sarah Patrick

News Feed Item

Top Ten Companies in DNA Sequencing

NEW YORK, Oct. 17, 2012 /PRNewswire/ -- Reportlinker.com announces that a new market research report is available in its catalogue:

 

Top Ten Companies in DNA Sequencing

http://www.reportlinker.com/p01013573/Top-Ten-Companies-in-DNA-Sequencin...

 

INTRODUCTION

 

The story of molecular biology is being both written and printed by sequencing tools—various chapters being currently authored by oncologists, ID experts, pathologists, and so forth. The narrative is understood by only those select few who have the cross discipline knowledge to comprehend what the sequencing tools output, and who also have the niche domain experience to act upon knowledge of that data. Recently, this story has begun to change as low cost next generation sequencing democratizes genome data, allowing a politics and commerce of inclusion, to enter the lab and now also the clinic.

 

Diagnostic manufacturers can now afford to develop sequencing tools as diagnostic shortcuts. The clinician does not need to understand the mathematical underpinnings of 16SrRNA coverage for phylogeny to run a rapid anthrax test.

 

Tandem repeats and retrotransposons have been conveniently converted into a "plus" or "minus" sign—a red light/green light clinical decision.

 

When Watson and Crick let the genie out of the research bottle, it was inevitable that this day would arrive—the only question was when it would happen. The types of automation that enabled cost efficiencies in sequencing tools have become decision tree shortcuts in the clinic, whereupon the first tangible fruits from the promise of personalized medicine have become apparent.

 

DNA sequencing is a strategic genomics tool that allows us to study how the genome varies among individuals and how that variation correlates to disease. Sequencing technologies are a critical part of today's life-science industry, affecting a wide range of activity from drug discovery to diagnostics. This focused document profiles the top 10 companies of the industry and explores the underlying technologies driving the industry's growth. Each technology is analyzed to determine its market status, impact on future market segments, and future growth potential. It should be noted that sequencing costs may only contribute 10% to 20% of a typical biomedical projects overall costs.

 

Of significance is the large occurrence of collaboration and co-ownership among the top players. Certain individuals, such as Mike Hunkapller and George Church, appear and reappear in several of the leading companies as co-founder, adviser or board member. But investment in seemingly rival efforts is also unusually high, underscoring both the connected nature of the research and commercial community, and also a "quantitative easing" or de-risking of being on the right team when the eventual winners are crowned in this high stakes field.

For this top 10 report, many factors were considered when selecting the companies. In general, chosen companies have a solid foundation built around their sequencing technology and have done an excellent job strategically positioning themselves into one (or many) of the facets of the industry.

 

In a reply to BCC from one of the top sequencing industry leaders, George Church explains in more detail some of the technological specifics to success. Next generation sequencing (NGS) systems are evolving rapidly, meaning this should be a core area of focus for a company should they want to excel now and in the near future.

 

Of the NGS systems, benchtop sequencers have a good niche currently. Although they can't process as much as the larger high-throughput systems, being smaller has its obvious advantages. In the long term, benchtop sequencers may end up getting squeezed out of their niche however, finding no room for successful commercialization between the large high-throughput systems and handheld or portable sequencers which are based around nanopore technology.

 

At this stage there are several different approaches different companies are working on concerning nanopore-based technologies. Leading the way in this sector of sequencing will certainly help strengthen any company and their competitive position. Many companies are competing, and to a certain extent this is a race of scaling, that is, who can get the most nanopores into the smallest area.

 

One of the problems that arise from the sequencing process is the flood of data that results. A key issue to note is just how well informatics will be able to handle this data flood. As read lengths become longer and more accurate, the informatics becomes easier. Interpretation of the data is another issue that arises, but focusing on medically actionable determinations should simplify rather than complicate the interpretation of results.

 

Another point to consider is whole genome sequencing, a goal for many. Applications from this process becoming available everywhere at low cost aren't too far into the future at the moment. One application has already emerged, a test for 2,400 highly predictive medical genetic diseases. This is superior to exome testing as these have the serious flaw of missing phasing information. For example, if a genome has mutations on say exon number 2 and exon number 7 of a gene, the exome doesn't distinguish between two hits in one gene copy (the other copy is fine) vs. hits in both copies (no healthy copies).

 

Given these criteria to success, along with other factors which BCC chose to examine, BCC has selected these 10 companies for this report that we feel are deserving of recognition and are leaders in their industry, This list includes:

 

Agilent Technologies Inc.

Genia

International Business Machines Corp.

Illumina Inc.

Knome Inc.

Life Technologies

Oxford Nanopore Technologies

Pacific Biosciences

Raindance Technologies Inc.

Roche Holding AG.

 

As any top 10 list is invariably subjective, there are also several companies profiled in less detail. These companies were on the bubble, or should be watched in the near future.

 

STUDY GOALS AND OBJECTIVES

 

This document is a specialty report related to the BCC Research report BIO045D authored by John Bergin. The goal of this document is to provide a more in-depth look at the top tier DNA sequencing companies as well as some of the second tier companies to look for in the near future, and to note the technological changes within the DNA sequencing industry that are sure to play a role in the years to come.

 

More specifically, the objectives include identifying companies that are considered the leaders in their field and the technological means these companies are using to exploit their markets and dominate their field. Key technology points explored include:

 

How the NGS (next generation sequencing) benchtop systems will do versus the larger, high throughput systems.

How well NGS systems will penetrate into diagnostics.

Which up and coming nanopore-based technologies will emerge and how will this affect market applications.

How well will sequencing informatics be able to solve the data flood.

When will mass whole genome sequencing applications emerge.

 

Other major factors used to determine top companies in the field include:

 

Alliance, merger, and acquisition strategy.

Financing.

Intellectual property (patent) portfolio.

 

INTENDED AUDIENCE

 

This study will be of particular interest to life-science research tools suppliers, pharmaceutical, diagnostics, nanotechnology, bioinformatics, semiconductor, and biotechnology companies. It will also be valuable to companies involved in genome sequencing projects, sequencing centers, manufacturers of microarrays, suppliers of molecular diagnostics assays, bioinformatics companies, and cancer researchers and clinicians. As this report is a profiling of top companies in the DNA sequencing field, the main audience should also include executive management personnel and marketing and financial analysts.

 

SCOPE

 

The scope of this report is focused on a select 10 companies in DNA sequencing, and the key areas in the field that are driving industry growth allowing these companies to succeed. These areas include Sanger, next-generation, and emerging sequencing technologies; the markets for sample preparation products, sequencing instruments and consumables; and bioinformatics and sequencing services. A key area BCC also explores is industry structure, noting strategic alliances and acquisitions along with pertinent patent information.

 

METHODOLOGY

 

Based on primary and secondary market analysis, this report analyzes the top 10 companies in DNA sequencing as well as some additional companies worth recognizing.

 

 

 

TABLE OF CONTENTS

 

CHAPTER 1 INTRODUCTION 1

STUDY GOALS AND OBJECTIVES 2

INTENDED AUDIENCE 3

SCOPE 3

METHODOLOGY 3

RELATED BCC REPORTS 3

BCC ONLINE SERVICES 4

DISCLAIMER 4

CHAPTER 2 DNA SEQUENCING TECHNOLOGY OVERVIEW 6

HISTORY 6

COST BREAKDOWN 7

CURRENT TECHNOLOGY OVERVIEW 7

TABLE 1 LIFE CYCLE OF DNA SEQUENCING TECHNOLOGIES 7

SANGER SEQUENCING 8

NEXT GENERATION SEQUENCING (NGS) 8

EMERGING SEQUENCING 8

TABLE 2 SEQUENCING INSTRUMENT COMPETITORS BY TECHNOLOGY 9

SANGER SEQUENCING 9

NEXT GENERATION SEQUENCING 10

NEXT GENERATION APPLICATIONS PARTIALLY ENABLED BY LOWER COSTS 10

NGS INSTRUMENT MARKET 11

TABLE 3 NGS INSTRUMENT MARKET SHARE IN 2011 ($ MILLIONS/%) 11

EMERGING SEQUENCING TECHNOLOGIES 12

TABLE 4 EMERGING SEQUENCING TECHNOLOGIES 12

TABLE 5 TOP COMPANIES IN EMERGING SEQUENCING INDUSTRY 13

BENCHTOP SEQUENCERS 13

TABLE 6 BENCHTOP SEQUENCING TECHNOLOGIES 13

SAMPLE PREPARATION REAGENTS AND KITS 13

TABLE 7 SEQUENCING SAMPLE PREPARATION COMPANY POSITIONING 14

SEQUENCE CAPTURE INDUSTRY 14

BIOINFORMATICS TECHNOLOGIES 14

TABLE 8 NGS SEQUENCING BIOINFORMATICS WORKFLOW 15

SEQUENCING SERVICES 16

CHAPTER 3 MARKET SUMMARY 18

MARKET GROWTH 18

TABLE 9 DNA SEQUENCING KEY GROWTH DRIVING FORCES 18

OVERALL MARKET 19

TABLE 10 GLOBAL VALUE OF SEQUENCING PRODUCTS AND SERVICES BY TYPE, THROUGH

2016 ($ MILLIONS) 19

INSTRUMENTS AND CONSUMABLES 19

TABLE 11 GLOBAL VALUE OF THE SEQUENCING INSTRUMENTS AND CONSUMABLES

MARKET BY PRODUCT TYPE, THROUGH 2016 ($ MILLIONS) 19

INSTRUMENTS 20

TABLE 12 GLOBAL VALUE OF SEQUENCING INSTRUMENTS BY PLATFORM, THROUGH 2016

($ MILLIONS) 20

CONSUMABLES 20

SEQUENCING SERVICES 21

TABLE 13 GLOBAL VALUE OF SEQUENCING SERVICES BY END-USER MARKET, THROUGH

2016 ($ MILLIONS) 21

CLINICAL DIAGNOSTICS 21

R&D, PHARMA, BIOTECH 22

WORKFLOW PRODUCTS 22

SAMPLE PREP 22

BIOINFORMATICS 23

GLOBAL SEQUENCING MARKET BROKEN DOWN BY REGION 23

CHAPTER 4 SEQUENCING PATENT ANALYSIS 26

FIGURE 1 SEQUENCING PATENTS, 2001–2011 (NO. OF PATENTS) 26

FIGURE 2 SEQUENCING PATENTS BY REGION, 2001–2011 (NO. OF PATENTS) 27

FIGURE 3 EMERGING SEQUENCING COMPANY PATENTS BY REGION 28

CHAPTER 5 THE TOP 10 COMPANIES IN DNA SEQUENCING 31

AGILENT TECHNOLOGIES INC. 31

STRATEGIC ALLIANCES 32

FINANCIALS 33

KEY MANAGEMENT 33

GENIA 33

TABLE 14 COMMERCIAL SEQUENCER COMPETITIVE POSITIONING 34

TECHNOLOGY 34

KEY MANAGEMENT 35

INTERNATIONAL BUSINESS MACHINES CORP. 35

KEY MANAGEMENT 37

ILLUMINA, INC. 37

ALLIANCES, MERGERS, AND ACQUISITIONS 38

ILLUMINA AND NGS 39

TABLE 15 ILLUMINA SEQUENCING PORTFOLIO BY INSTRUMENT ($ PER YEAR) 39

KEY MANAGEMENT 40

KNOME INC. 40

TABLE 16 KNOME'S BREAKDOWN OF VARIANTS 41

STRATEGIC ALLIANCES 41

KEY MANAGEMENT 42

LIFE TECHNOLOGIES INC. 42

ION TORRENT TECHNOLOGY 44

SANGER SEQUENCING 44

TABLE 17 LIFE TECHNOLOGIES' 3500DX INSTRUMENTS 45

NGS 45

TABLE 18 5500 SERIES GENETIC ANALYSIS SYSTEMS SPECIFICATIONS 45

THIRD GENERATION SEQUENCING 46

KEY ACQUISITIONS 46

MANAGEMENT 47

OXFORD NANOPORE TECHNOLOGIES 47

FINANCE HISTORY 48

TECHNOLOGY 48

KEY MANAGEMENT 49

PACIFIC BIOSCIENCES 49

ALLIANCES 51

Gen-Probe 51

Cycle Computing 51

LI-COR 51

Others 51

FINANCIALS 52

INITIAL PUBLIC OFFERING 52

EMPLOYEES AND LAYOFFS 52

INTELLECTUAL PROPERTY 52

MANAGEMENT 53

RAINDANCE TECHNOLOGIES INC. 53

TECHNOLOGY 53

SEQUENCE CAPTURE PANELS 54

TABLE 19 RAINDANCE RESEARCH SCREENING PANELS 54

STRATEGIC ALLIANCES 55

TABLE 20 RAINDANCE STRATEGIC ALLIANCES 55

RECENT FINANCES 56

MANAGEMENT 56

ROCHE HOLDING AG 57

TABLE 21 ROCHE DIAGNOSTICS SALES, BY REGION 2011 (%) 57

TABLE 22 ROCHE 454 SEQUENCING SYSTEMS COMPARISON 58

NIMBLEGEN 58

FLUIDIGM 59

IBM 59

MANAGEMENT 60

OTHER COMPANIES TO WATCH 60

BGI 60

COMPLETE GENOMICS INC. 61

DANAHER 62

FLUIDIGM CORPORATION 62

GEN-PROBE INC. 63

HELICOS BIOSCIENCES CORPORATION 63

NUGEN TECHNOLOGIES INC. 64

 

LIST OF TABLES

TABLE 1 LIFE CYCLE OF DNA SEQUENCING TECHNOLOGIES 7

TABLE 2 SEQUENCING INSTRUMENT COMPETITORS BY TECHNOLOGY 9

TABLE 3 NGS INSTRUMENT MARKET SHARE IN 2011 ($ MILLIONS/%) 11

TABLE 4 EMERGING SEQUENCING TECHNOLOGIES 12

TABLE 5 TOP COMPANIES IN EMERGING SEQUENCING INDUSTRY 13

TABLE 6 BENCHTOP SEQUENCING TECHNOLOGIES 13

TABLE 7 SEQUENCING SAMPLE PREPARATION COMPANY POSITIONING 14

TABLE 8 NGS SEQUENCING BIOINFORMATICS WORKFLOW 15

TABLE 9 DNA SEQUENCING KEY GROWTH DRIVING FORCES 18

TABLE 10 GLOBAL VALUE OF SEQUENCING PRODUCTS AND SERVICES BY TYPE, THROUGH

2016 ($ MILLIONS) 19

TABLE 11 GLOBAL VALUE OF THE SEQUENCING INSTRUMENTS AND CONSUMABLES

MARKET BY PRODUCT TYPE, THROUGH 2016 ($ MILLIONS) 19

TABLE 12 GLOBAL VALUE OF SEQUENCING INSTRUMENTS BY PLATFORM, THROUGH 2016

($ MILLIONS) 20

TABLE 13 GLOBAL VALUE OF SEQUENCING SERVICES BY END-USER MARKET, THROUGH

2016 ($ MILLIONS) 21

TABLE 14 COMMERCIAL SEQUENCER COMPETITIVE POSITIONING 34

TABLE 15 ILLUMINA SEQUENCING PORTFOLIO BY INSTRUMENT ($ PER YEAR) 39

TABLE 16 KNOME'S BREAKDOWN OF VARIANTS 41

TABLE 17 LIFE TECHNOLOGIES' 3500DX INSTRUMENTS 45

TABLE 18 5500 SERIES GENETIC ANALYSIS SYSTEMS SPECIFICATIONS 45

TABLE 19 RAINDANCE RESEARCH SCREENING PANELS 54

TABLE 20 RAINDANCE STRATEGIC ALLIANCES 55

TABLE 21 ROCHE DIAGNOSTICS SALES, BY REGION 2011 (%) 57

TABLE 22 ROCHE 454 SEQUENCING SYSTEMS COMPARISON 58

 

LIST OF FIGURES

FIGURE 1 SEQUENCING PATENTS, 2001–2011 (NO. OF PATENTS) 26

FIGURE 2 SEQUENCING PATENTS BY REGION, 2001–2011 (NO. OF PATENTS) 27

FIGURE 3 EMERGING SEQUENCING COMPANY PATENTS BY REGION 28

 

 

 

To order this report:

Genomics Industry: Top Ten Companies in DNA Sequencing

 

Nicolas Bombourg
Reportlinker
Email: nicolasbombourg@reportlinker.com
US: (805)652-2626
Intl: +1 805-652-2626

 

SOURCE Reportlinker

More Stories By PR Newswire

Copyright © 2007 PR Newswire. All rights reserved. Republication or redistribution of PRNewswire content is expressly prohibited without the prior written consent of PRNewswire. PRNewswire shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon.

@ThingsExpo Stories
SYS-CON Events announced today that Men & Mice, the leading global provider of DNS, DHCP and IP address management overlay solutions, will exhibit at SYS-CON's 18th International Cloud Expo®, which will take place on June 7-9, 2016, at the Javits Center in New York City, NY. The Men & Mice Suite overlay solution is already known for its powerful application in heterogeneous operating environments, enabling enterprises to scale without fuss. Building on a solid range of diverse platform support,...
With an estimated 50 billion devices connected to the Internet by 2020, several industries will begin to expand their capabilities for retaining end point data at the edge to better utilize the range of data types and sheer volume of M2M data generated by the Internet of Things. In his session at @ThingsExpo, Don DeLoach, CEO and President of Infobright, will discuss the infrastructures businesses will need to implement to handle this explosion of data by providing specific use cases for filte...
SYS-CON Events announced today that Pythian, a global IT services company specializing in helping companies adopt disruptive technologies to optimize revenue-generating systems, has been named “Bronze Sponsor” of SYS-CON's 18th Cloud Expo, which will take place on June 7-9, 2015 at the Javits Center in New York, New York. Founded in 1997, Pythian is a global IT services company that helps companies compete by adopting disruptive technologies such as cloud, Big Data, advanced analytics, and DevO...
Fortunately, meaningful and tangible business cases for IoT are plentiful in a broad array of industries and vertical markets. These range from simple warranty cost reduction for capital intensive assets, to minimizing downtime for vital business tools, to creating feedback loops improving product design, to improving and enhancing enterprise customer experiences. All of these business cases, which will be briefly explored in this session, hinge on cost effectively extracting relevant data from ...
SYS-CON Events announced today that iDevices®, the preeminent brand in the connected home industry, will exhibit at SYS-CON's 18th International Cloud Expo®, which will take place on June 7-9, 2016, at the Javits Center in New York City, NY. iDevices, the preeminent brand in the connected home industry, has a growing line of HomeKit-enabled products available at the largest retailers worldwide. Through the “Designed with iDevices” co-development program and its custom-built IoT Cloud Infrastruc...
SYS-CON Events announced today that Commvault, a global leader in enterprise data protection and information management, has been named “Bronze Sponsor” of SYS-CON's 18th International Cloud Expo, which will take place on June 7–9, 2016, at the Javits Center in New York City, NY, and the 19th International Cloud Expo, which will take place on November 1–3, 2016, at the Santa Clara Convention Center in Santa Clara, CA. Commvault is a leading provider of data protection and information management...
As enterprises work to take advantage of Big Data technologies, they frequently become distracted by product-level decisions. In most new Big Data builds this approach is completely counter-productive: it presupposes tools that may not be a fit for development teams, forces IT to take on the burden of evaluating and maintaining unfamiliar technology, and represents a major up-front expense. In his session at @BigDataExpo at @ThingsExpo, Andrew Warfield, CTO and Co-Founder of Coho Data, will dis...
Eighty percent of a data scientist’s time is spent gathering and cleaning up data, and 80% of all data is unstructured and almost never analyzed. Cognitive computing, in combination with Big Data, is changing the equation by creating data reservoirs and using natural language processing to enable analysis of unstructured data sources. This is impacting every aspect of the analytics profession from how data is mined (and by whom) to how it is delivered. This is not some futuristic vision: it's ha...
With the Apple Watch making its way onto wrists all over the world, it’s only a matter of time before it becomes a staple in the workplace. In fact, Forrester reported that 68 percent of technology and business decision-makers characterize wearables as a top priority for 2015. Recognizing their business value early on, FinancialForce.com was the first to bring ERP to wearables, helping streamline communication across front and back office functions. In his session at @ThingsExpo, Kevin Roberts...
One of the bewildering things about DevOps is integrating the massive toolchain including the dozens of new tools that seem to crop up every year. Part of DevOps is Continuous Delivery and having a complex toolchain can add additional integration and setup to your developer environment. In his session at @DevOpsSummit at 18th Cloud Expo, Miko Matsumura, Chief Marketing Officer of Gradle Inc., will discuss which tools to use in a developer stack, how to provision the toolchain to minimize onboa...
Cognitive Computing is becoming the foundation for a new generation of solutions that have the potential to transform business. Unlike traditional approaches to building solutions, a cognitive computing approach allows the data to help determine the way applications are designed. This contrasts with conventional software development that begins with defining logic based on the current way a business operates. In her session at 18th Cloud Expo, Judith S. Hurwitz, President and CEO of Hurwitz & ...
The cloud promises new levels of agility and cost-savings for Big Data, data warehousing and analytics. But it’s challenging to understand all the options – from IaaS and PaaS to newer services like HaaS (Hadoop as a Service) and BDaaS (Big Data as a Service). In her session at @BigDataExpo at @ThingsExpo, Hannah Smalltree, a director at Cazena, will provide an educational overview of emerging “as-a-service” options for Big Data in the cloud. This is critical background for IT and data profes...
SYS-CON Events announced today that VAI, a leading ERP software provider, will exhibit at SYS-CON's 18th International Cloud Expo®, which will take place on June 7-9, 2016, at the Javits Center in New York City, NY. VAI (Vormittag Associates, Inc.) is a leading independent mid-market ERP software developer renowned for its flexible solutions and ability to automate critical business functions for the distribution, manufacturing, specialty retail and service sectors. An IBM Premier Business Part...
SYS-CON Events announced today that Alert Logic, Inc., the leading provider of Security-as-a-Service solutions for the cloud, will exhibit at SYS-CON's 18th International Cloud Expo®, which will take place on June 7-9, 2016, at the Javits Center in New York City, NY. Alert Logic, Inc., provides Security-as-a-Service for on-premises, cloud, and hybrid infrastructures, delivering deep security insight and continuous protection for customers at a lower cost than traditional security solutions. Ful...
SYS-CON Events announced today that Interoute, owner-operator of one of Europe's largest networks and a global cloud services platform, has been named “Bronze Sponsor” of SYS-CON's 18th Cloud Expo, which will take place on June 7-9, 2015 at the Javits Center in New York, New York. Interoute is the owner-operator of one of Europe's largest networks and a global cloud services platform which encompasses 12 data centers, 14 virtual data centers and 31 colocation centers, with connections to 195 ad...
SYS-CON Events announced today that Fusion, a leading provider of cloud services, will exhibit at SYS-CON's 18th International Cloud Expo®, which will take place on June 7-9, 2016, at the Javits Center in New York City, NY. Fusion, a leading provider of integrated cloud solutions to small, medium and large businesses, is the industry's single source for the cloud. Fusion's advanced, proprietary cloud service platform enables the integration of leading edge solutions in the cloud, including clou...
Most people haven’t heard the word, “gamification,” even though they probably, and perhaps unwittingly, participate in it every day. Gamification is “the process of adding games or game-like elements to something (as a task) so as to encourage participation.” Further, gamification is about bringing game mechanics – rules, constructs, processes, and methods – into the real world in an effort to engage people. In his session at @ThingsExpo, Robert Endo, owner and engagement manager of Intrepid D...
WebRTC has had a real tough three or four years, and so have those working with it. Only a few short years ago, the development world were excited about WebRTC and proclaiming how awesome it was. You might have played with the technology a couple of years ago, only to find the extra infrastructure requirements were painful to implement and poorly documented. This probably left a bitter taste in your mouth, especially when things went wrong.
Learn how IoT, cloud, social networks and last but not least, humans, can be integrated into a seamless integration of cooperative organisms both cybernetic and biological. This has been enabled by recent advances in IoT device capabilities, messaging frameworks, presence and collaboration services, where devices can share information and make independent and human assisted decisions based upon social status from other entities. In his session at @ThingsExpo, Michael Heydt, founder of Seamless...
The IoT's basic concept of collecting data from as many sources possible to drive better decision making, create process innovation and realize additional revenue has been in use at large enterprises with deep pockets for decades. So what has changed? In his session at @ThingsExpo, Prasanna Sivaramakrishnan, Solutions Architect at Red Hat, discussed the impact commodity hardware, ubiquitous connectivity, and innovations in open source software are having on the connected universe of people, thi...