Welcome!

Websphere Authors: Yeshim Deniz, Carmen Gonzalez, Sanjeev Sharma, Liz McMillan, Elizabeth White

News Feed Item

Top Ten Companies in DNA Sequencing

NEW YORK, Oct. 17, 2012 /PRNewswire/ -- Reportlinker.com announces that a new market research report is available in its catalogue:

 

Top Ten Companies in DNA Sequencing

http://www.reportlinker.com/p01013573/Top-Ten-Companies-in-DNA-Sequencin...

 

INTRODUCTION

 

The story of molecular biology is being both written and printed by sequencing tools—various chapters being currently authored by oncologists, ID experts, pathologists, and so forth. The narrative is understood by only those select few who have the cross discipline knowledge to comprehend what the sequencing tools output, and who also have the niche domain experience to act upon knowledge of that data. Recently, this story has begun to change as low cost next generation sequencing democratizes genome data, allowing a politics and commerce of inclusion, to enter the lab and now also the clinic.

 

Diagnostic manufacturers can now afford to develop sequencing tools as diagnostic shortcuts. The clinician does not need to understand the mathematical underpinnings of 16SrRNA coverage for phylogeny to run a rapid anthrax test.

 

Tandem repeats and retrotransposons have been conveniently converted into a "plus" or "minus" sign—a red light/green light clinical decision.

 

When Watson and Crick let the genie out of the research bottle, it was inevitable that this day would arrive—the only question was when it would happen. The types of automation that enabled cost efficiencies in sequencing tools have become decision tree shortcuts in the clinic, whereupon the first tangible fruits from the promise of personalized medicine have become apparent.

 

DNA sequencing is a strategic genomics tool that allows us to study how the genome varies among individuals and how that variation correlates to disease. Sequencing technologies are a critical part of today's life-science industry, affecting a wide range of activity from drug discovery to diagnostics. This focused document profiles the top 10 companies of the industry and explores the underlying technologies driving the industry's growth. Each technology is analyzed to determine its market status, impact on future market segments, and future growth potential. It should be noted that sequencing costs may only contribute 10% to 20% of a typical biomedical projects overall costs.

 

Of significance is the large occurrence of collaboration and co-ownership among the top players. Certain individuals, such as Mike Hunkapller and George Church, appear and reappear in several of the leading companies as co-founder, adviser or board member. But investment in seemingly rival efforts is also unusually high, underscoring both the connected nature of the research and commercial community, and also a "quantitative easing" or de-risking of being on the right team when the eventual winners are crowned in this high stakes field.

For this top 10 report, many factors were considered when selecting the companies. In general, chosen companies have a solid foundation built around their sequencing technology and have done an excellent job strategically positioning themselves into one (or many) of the facets of the industry.

 

In a reply to BCC from one of the top sequencing industry leaders, George Church explains in more detail some of the technological specifics to success. Next generation sequencing (NGS) systems are evolving rapidly, meaning this should be a core area of focus for a company should they want to excel now and in the near future.

 

Of the NGS systems, benchtop sequencers have a good niche currently. Although they can't process as much as the larger high-throughput systems, being smaller has its obvious advantages. In the long term, benchtop sequencers may end up getting squeezed out of their niche however, finding no room for successful commercialization between the large high-throughput systems and handheld or portable sequencers which are based around nanopore technology.

 

At this stage there are several different approaches different companies are working on concerning nanopore-based technologies. Leading the way in this sector of sequencing will certainly help strengthen any company and their competitive position. Many companies are competing, and to a certain extent this is a race of scaling, that is, who can get the most nanopores into the smallest area.

 

One of the problems that arise from the sequencing process is the flood of data that results. A key issue to note is just how well informatics will be able to handle this data flood. As read lengths become longer and more accurate, the informatics becomes easier. Interpretation of the data is another issue that arises, but focusing on medically actionable determinations should simplify rather than complicate the interpretation of results.

 

Another point to consider is whole genome sequencing, a goal for many. Applications from this process becoming available everywhere at low cost aren't too far into the future at the moment. One application has already emerged, a test for 2,400 highly predictive medical genetic diseases. This is superior to exome testing as these have the serious flaw of missing phasing information. For example, if a genome has mutations on say exon number 2 and exon number 7 of a gene, the exome doesn't distinguish between two hits in one gene copy (the other copy is fine) vs. hits in both copies (no healthy copies).

 

Given these criteria to success, along with other factors which BCC chose to examine, BCC has selected these 10 companies for this report that we feel are deserving of recognition and are leaders in their industry, This list includes:

 

Agilent Technologies Inc.

Genia

International Business Machines Corp.

Illumina Inc.

Knome Inc.

Life Technologies

Oxford Nanopore Technologies

Pacific Biosciences

Raindance Technologies Inc.

Roche Holding AG.

 

As any top 10 list is invariably subjective, there are also several companies profiled in less detail. These companies were on the bubble, or should be watched in the near future.

 

STUDY GOALS AND OBJECTIVES

 

This document is a specialty report related to the BCC Research report BIO045D authored by John Bergin. The goal of this document is to provide a more in-depth look at the top tier DNA sequencing companies as well as some of the second tier companies to look for in the near future, and to note the technological changes within the DNA sequencing industry that are sure to play a role in the years to come.

 

More specifically, the objectives include identifying companies that are considered the leaders in their field and the technological means these companies are using to exploit their markets and dominate their field. Key technology points explored include:

 

How the NGS (next generation sequencing) benchtop systems will do versus the larger, high throughput systems.

How well NGS systems will penetrate into diagnostics.

Which up and coming nanopore-based technologies will emerge and how will this affect market applications.

How well will sequencing informatics be able to solve the data flood.

When will mass whole genome sequencing applications emerge.

 

Other major factors used to determine top companies in the field include:

 

Alliance, merger, and acquisition strategy.

Financing.

Intellectual property (patent) portfolio.

 

INTENDED AUDIENCE

 

This study will be of particular interest to life-science research tools suppliers, pharmaceutical, diagnostics, nanotechnology, bioinformatics, semiconductor, and biotechnology companies. It will also be valuable to companies involved in genome sequencing projects, sequencing centers, manufacturers of microarrays, suppliers of molecular diagnostics assays, bioinformatics companies, and cancer researchers and clinicians. As this report is a profiling of top companies in the DNA sequencing field, the main audience should also include executive management personnel and marketing and financial analysts.

 

SCOPE

 

The scope of this report is focused on a select 10 companies in DNA sequencing, and the key areas in the field that are driving industry growth allowing these companies to succeed. These areas include Sanger, next-generation, and emerging sequencing technologies; the markets for sample preparation products, sequencing instruments and consumables; and bioinformatics and sequencing services. A key area BCC also explores is industry structure, noting strategic alliances and acquisitions along with pertinent patent information.

 

METHODOLOGY

 

Based on primary and secondary market analysis, this report analyzes the top 10 companies in DNA sequencing as well as some additional companies worth recognizing.

 

 

 

TABLE OF CONTENTS

 

CHAPTER 1 INTRODUCTION 1

STUDY GOALS AND OBJECTIVES 2

INTENDED AUDIENCE 3

SCOPE 3

METHODOLOGY 3

RELATED BCC REPORTS 3

BCC ONLINE SERVICES 4

DISCLAIMER 4

CHAPTER 2 DNA SEQUENCING TECHNOLOGY OVERVIEW 6

HISTORY 6

COST BREAKDOWN 7

CURRENT TECHNOLOGY OVERVIEW 7

TABLE 1 LIFE CYCLE OF DNA SEQUENCING TECHNOLOGIES 7

SANGER SEQUENCING 8

NEXT GENERATION SEQUENCING (NGS) 8

EMERGING SEQUENCING 8

TABLE 2 SEQUENCING INSTRUMENT COMPETITORS BY TECHNOLOGY 9

SANGER SEQUENCING 9

NEXT GENERATION SEQUENCING 10

NEXT GENERATION APPLICATIONS PARTIALLY ENABLED BY LOWER COSTS 10

NGS INSTRUMENT MARKET 11

TABLE 3 NGS INSTRUMENT MARKET SHARE IN 2011 ($ MILLIONS/%) 11

EMERGING SEQUENCING TECHNOLOGIES 12

TABLE 4 EMERGING SEQUENCING TECHNOLOGIES 12

TABLE 5 TOP COMPANIES IN EMERGING SEQUENCING INDUSTRY 13

BENCHTOP SEQUENCERS 13

TABLE 6 BENCHTOP SEQUENCING TECHNOLOGIES 13

SAMPLE PREPARATION REAGENTS AND KITS 13

TABLE 7 SEQUENCING SAMPLE PREPARATION COMPANY POSITIONING 14

SEQUENCE CAPTURE INDUSTRY 14

BIOINFORMATICS TECHNOLOGIES 14

TABLE 8 NGS SEQUENCING BIOINFORMATICS WORKFLOW 15

SEQUENCING SERVICES 16

CHAPTER 3 MARKET SUMMARY 18

MARKET GROWTH 18

TABLE 9 DNA SEQUENCING KEY GROWTH DRIVING FORCES 18

OVERALL MARKET 19

TABLE 10 GLOBAL VALUE OF SEQUENCING PRODUCTS AND SERVICES BY TYPE, THROUGH

2016 ($ MILLIONS) 19

INSTRUMENTS AND CONSUMABLES 19

TABLE 11 GLOBAL VALUE OF THE SEQUENCING INSTRUMENTS AND CONSUMABLES

MARKET BY PRODUCT TYPE, THROUGH 2016 ($ MILLIONS) 19

INSTRUMENTS 20

TABLE 12 GLOBAL VALUE OF SEQUENCING INSTRUMENTS BY PLATFORM, THROUGH 2016

($ MILLIONS) 20

CONSUMABLES 20

SEQUENCING SERVICES 21

TABLE 13 GLOBAL VALUE OF SEQUENCING SERVICES BY END-USER MARKET, THROUGH

2016 ($ MILLIONS) 21

CLINICAL DIAGNOSTICS 21

R&D, PHARMA, BIOTECH 22

WORKFLOW PRODUCTS 22

SAMPLE PREP 22

BIOINFORMATICS 23

GLOBAL SEQUENCING MARKET BROKEN DOWN BY REGION 23

CHAPTER 4 SEQUENCING PATENT ANALYSIS 26

FIGURE 1 SEQUENCING PATENTS, 2001–2011 (NO. OF PATENTS) 26

FIGURE 2 SEQUENCING PATENTS BY REGION, 2001–2011 (NO. OF PATENTS) 27

FIGURE 3 EMERGING SEQUENCING COMPANY PATENTS BY REGION 28

CHAPTER 5 THE TOP 10 COMPANIES IN DNA SEQUENCING 31

AGILENT TECHNOLOGIES INC. 31

STRATEGIC ALLIANCES 32

FINANCIALS 33

KEY MANAGEMENT 33

GENIA 33

TABLE 14 COMMERCIAL SEQUENCER COMPETITIVE POSITIONING 34

TECHNOLOGY 34

KEY MANAGEMENT 35

INTERNATIONAL BUSINESS MACHINES CORP. 35

KEY MANAGEMENT 37

ILLUMINA, INC. 37

ALLIANCES, MERGERS, AND ACQUISITIONS 38

ILLUMINA AND NGS 39

TABLE 15 ILLUMINA SEQUENCING PORTFOLIO BY INSTRUMENT ($ PER YEAR) 39

KEY MANAGEMENT 40

KNOME INC. 40

TABLE 16 KNOME'S BREAKDOWN OF VARIANTS 41

STRATEGIC ALLIANCES 41

KEY MANAGEMENT 42

LIFE TECHNOLOGIES INC. 42

ION TORRENT TECHNOLOGY 44

SANGER SEQUENCING 44

TABLE 17 LIFE TECHNOLOGIES' 3500DX INSTRUMENTS 45

NGS 45

TABLE 18 5500 SERIES GENETIC ANALYSIS SYSTEMS SPECIFICATIONS 45

THIRD GENERATION SEQUENCING 46

KEY ACQUISITIONS 46

MANAGEMENT 47

OXFORD NANOPORE TECHNOLOGIES 47

FINANCE HISTORY 48

TECHNOLOGY 48

KEY MANAGEMENT 49

PACIFIC BIOSCIENCES 49

ALLIANCES 51

Gen-Probe 51

Cycle Computing 51

LI-COR 51

Others 51

FINANCIALS 52

INITIAL PUBLIC OFFERING 52

EMPLOYEES AND LAYOFFS 52

INTELLECTUAL PROPERTY 52

MANAGEMENT 53

RAINDANCE TECHNOLOGIES INC. 53

TECHNOLOGY 53

SEQUENCE CAPTURE PANELS 54

TABLE 19 RAINDANCE RESEARCH SCREENING PANELS 54

STRATEGIC ALLIANCES 55

TABLE 20 RAINDANCE STRATEGIC ALLIANCES 55

RECENT FINANCES 56

MANAGEMENT 56

ROCHE HOLDING AG 57

TABLE 21 ROCHE DIAGNOSTICS SALES, BY REGION 2011 (%) 57

TABLE 22 ROCHE 454 SEQUENCING SYSTEMS COMPARISON 58

NIMBLEGEN 58

FLUIDIGM 59

IBM 59

MANAGEMENT 60

OTHER COMPANIES TO WATCH 60

BGI 60

COMPLETE GENOMICS INC. 61

DANAHER 62

FLUIDIGM CORPORATION 62

GEN-PROBE INC. 63

HELICOS BIOSCIENCES CORPORATION 63

NUGEN TECHNOLOGIES INC. 64

 

LIST OF TABLES

TABLE 1 LIFE CYCLE OF DNA SEQUENCING TECHNOLOGIES 7

TABLE 2 SEQUENCING INSTRUMENT COMPETITORS BY TECHNOLOGY 9

TABLE 3 NGS INSTRUMENT MARKET SHARE IN 2011 ($ MILLIONS/%) 11

TABLE 4 EMERGING SEQUENCING TECHNOLOGIES 12

TABLE 5 TOP COMPANIES IN EMERGING SEQUENCING INDUSTRY 13

TABLE 6 BENCHTOP SEQUENCING TECHNOLOGIES 13

TABLE 7 SEQUENCING SAMPLE PREPARATION COMPANY POSITIONING 14

TABLE 8 NGS SEQUENCING BIOINFORMATICS WORKFLOW 15

TABLE 9 DNA SEQUENCING KEY GROWTH DRIVING FORCES 18

TABLE 10 GLOBAL VALUE OF SEQUENCING PRODUCTS AND SERVICES BY TYPE, THROUGH

2016 ($ MILLIONS) 19

TABLE 11 GLOBAL VALUE OF THE SEQUENCING INSTRUMENTS AND CONSUMABLES

MARKET BY PRODUCT TYPE, THROUGH 2016 ($ MILLIONS) 19

TABLE 12 GLOBAL VALUE OF SEQUENCING INSTRUMENTS BY PLATFORM, THROUGH 2016

($ MILLIONS) 20

TABLE 13 GLOBAL VALUE OF SEQUENCING SERVICES BY END-USER MARKET, THROUGH

2016 ($ MILLIONS) 21

TABLE 14 COMMERCIAL SEQUENCER COMPETITIVE POSITIONING 34

TABLE 15 ILLUMINA SEQUENCING PORTFOLIO BY INSTRUMENT ($ PER YEAR) 39

TABLE 16 KNOME'S BREAKDOWN OF VARIANTS 41

TABLE 17 LIFE TECHNOLOGIES' 3500DX INSTRUMENTS 45

TABLE 18 5500 SERIES GENETIC ANALYSIS SYSTEMS SPECIFICATIONS 45

TABLE 19 RAINDANCE RESEARCH SCREENING PANELS 54

TABLE 20 RAINDANCE STRATEGIC ALLIANCES 55

TABLE 21 ROCHE DIAGNOSTICS SALES, BY REGION 2011 (%) 57

TABLE 22 ROCHE 454 SEQUENCING SYSTEMS COMPARISON 58

 

LIST OF FIGURES

FIGURE 1 SEQUENCING PATENTS, 2001–2011 (NO. OF PATENTS) 26

FIGURE 2 SEQUENCING PATENTS BY REGION, 2001–2011 (NO. OF PATENTS) 27

FIGURE 3 EMERGING SEQUENCING COMPANY PATENTS BY REGION 28

 

 

 

To order this report:

Genomics Industry: Top Ten Companies in DNA Sequencing

 

Nicolas Bombourg
Reportlinker
Email: nicolasbombourg@reportlinker.com
US: (805)652-2626
Intl: +1 805-652-2626

 

SOURCE Reportlinker

More Stories By PR Newswire

Copyright © 2007 PR Newswire. All rights reserved. Republication or redistribution of PRNewswire content is expressly prohibited without the prior written consent of PRNewswire. PRNewswire shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon.

@ThingsExpo Stories
Focused on this fast-growing market’s needs, Vitesse Semiconductor Corporation (Nasdaq: VTSS), a leading provider of IC solutions to advance "Ethernet Everywhere" in Carrier, Enterprise and Internet of Things (IoT) networks, introduced its IStaX™ software (VSC6815SDK), a robust protocol stack to simplify deployment and management of Industrial-IoT network applications such as Industrial Ethernet switching, surveillance, video distribution, LCD signage, intelligent sensors, and metering equipment. Leveraging technologies proven in the Carrier and Enterprise markets, IStaX is designed to work ac...

ARMONK, N.Y., Nov. 20, 2014 /PRNewswire/ --  IBM (NYSE: IBM) today announced that it is bringing a greater level of control, security and flexibility to cloud-based application development and delivery with a single-tenant version of Bluemix, IBM's platform-as-a-service. The new platform enables developers to build ap...

"There is a natural synchronization between the business models, the IoT is there to support ,” explained Brendan O'Brien, Co-founder and Chief Architect of Aria Systems, in this SYS-CON.tv interview at the 15th International Cloud Expo®, held Nov 4–6, 2014, at the Santa Clara Convention Center in Santa Clara, CA.
C-Labs LLC, a leading provider of remote and mobile access for the Internet of Things (IoT), announced the appointment of John Traynor to the position of chief operating officer. Previously a strategic advisor to the firm, Mr. Traynor will now oversee sales, marketing, finance, and operations. Mr. Traynor is based out of the C-Labs office in Redmond, Washington. He reports to Chris Muench, Chief Executive Officer. Mr. Traynor brings valuable business leadership and technology industry expertise to C-Labs. With over 30 years' experience in the high-tech sector, John Traynor has held numerous...
Bit6 today issued a challenge to the technology community implementing Web Real Time Communication (WebRTC). To leap beyond WebRTC’s significant limitations and fully leverage its underlying value to accelerate innovation, application developers need to consider the entire communications ecosystem.
The 3rd International @ThingsExpo, co-located with the 16th International Cloud Expo - to be held June 9-11, 2015, at the Javits Center in New York City, NY - announces that it is now accepting Keynote Proposals. The Internet of Things (IoT) is the most profound change in personal and enterprise IT since the creation of the Worldwide Web more than 20 years ago. All major researchers estimate there will be tens of billions devices - computers, smartphones, tablets, and sensors - connected to the Internet by 2020. This number will continue to grow at a rapid pace for the next several decades.
The Internet of Things is not new. Historically, smart businesses have used its basic concept of leveraging data to drive better decision making and have capitalized on those insights to realize additional revenue opportunities. So, what has changed to make the Internet of Things one of the hottest topics in tech? In his session at @ThingsExpo, Chris Gray, Director, Embedded and Internet of Things, discussed the underlying factors that are driving the economics of intelligent systems. Discover how hardware commoditization, the ubiquitous nature of connectivity, and the emergence of Big Data a...
Almost everyone sees the potential of Internet of Things but how can businesses truly unlock that potential. The key will be in the ability to discover business insight in the midst of an ocean of Big Data generated from billions of embedded devices via Systems of Discover. Businesses will also need to ensure that they can sustain that insight by leveraging the cloud for global reach, scale and elasticity.
SYS-CON Events announced today that Windstream, a leading provider of advanced network and cloud communications, has been named “Silver Sponsor” of SYS-CON's 16th International Cloud Expo®, which will take place on June 9–11, 2015, at the Javits Center in New York, NY. Windstream (Nasdaq: WIN), a FORTUNE 500 and S&P 500 company, is a leading provider of advanced network communications, including cloud computing and managed services, to businesses nationwide. The company also offers broadband, phone and digital TV services to consumers primarily in rural areas.
SYS-CON Events announced today that IDenticard will exhibit at SYS-CON's 16th International Cloud Expo®, which will take place on June 9-11, 2015, at the Javits Center in New York City, NY. IDenticard™ is the security division of Brady Corp (NYSE: BRC), a $1.5 billion manufacturer of identification products. We have small-company values with the strength and stability of a major corporation. IDenticard offers local sales, support and service to our customers across the United States and Canada. Our partner network encompasses some 300 of the world's leading systems integrators and security s...
IoT is still a vague buzzword for many people. In his session at @ThingsExpo, Mike Kavis, Vice President & Principal Cloud Architect at Cloud Technology Partners, discussed the business value of IoT that goes far beyond the general public's perception that IoT is all about wearables and home consumer services. He also discussed how IoT is perceived by investors and how venture capitalist access this space. Other topics discussed were barriers to success, what is new, what is old, and what the future may hold. Mike Kavis is Vice President & Principal Cloud Architect at Cloud Technology Pa...
Smart devices that use wireless technology to exchange information with each other and with their human owners: this is the Internet of Things (IoT). This incredible level of connectivity is already transforming how we exercise, treat diseases, park our cars and access business documents. Research firm IDC projects that the IoT world of connected devices will grow to 200 billion objects by 2020. As more businesses, entrepreneurs and government entities embrace the IoT, more data will be generated daily than the already mind-boggling 2.5 quintillion bytes of data per day. However, even curren...
The Industrial Revolution in the 18th to 19th centuries was a period during which predominantly rural societies in Europe and America became industrial and urban. Advances in steam technology, transportation, mass production and the telegraph collectively transformed industry and society. Today, the Internet of Things (IoT) has the potential to once again transform industry and society just as the Industrial Revolution did. Analyst firm IDC forecasts that the IoT market will grow to $8.9 trillion by 2020 with anywhere between 30 to 50 billion connected autonomous things, making the potential g...
Cloud Expo 2014 TV commercials will feature @ThingsExpo, which was launched in June, 2014 at New York City's Javits Center as the largest 'Internet of Things' event in the world. The next @ThingsExpo will take place November 4-6, 2014, at the Santa Clara Convention Center, in Santa Clara, California. Since its launch in 2008, Cloud Expo TV commercials have been aired and CNBC, Fox News Network, and Bloomberg TV. Please enjoy our 2014 commercial.
From a software development perspective IoT is about programming "things," about connecting them with each other or integrating them with existing applications. In his session at @ThingsExpo, Yakov Fain, co-founder of Farata Systems and SuranceBay, will show you how small IoT-enabled devices from multiple manufacturers can be integrated into the workflow of an enterprise application. This is a practical demo of building a framework and components in HTML/Java/Mobile technologies to serve as a platform that can integrate new devices as they become available on the market.
The 3rd International Internet of @ThingsExpo, co-located with the 16th International Cloud Expo - to be held June 9-11, 2015, at the Javits Center in New York City, NY - announces that its Call for Papers is now open. The Internet of Things (IoT) is the biggest idea since the creation of the Worldwide Web more than 20 years ago.
Located in booth #314, the Bsquare team will present DataV demos and discuss how DataV will help customers put their data to work to improve business outcomes. DataV is unlocking new initiatives across a wide landscape of customers in industries such as industrial manufacturing, transportation, retail and mobile. The solution is designed to complement a new project start or help to enrich an existing machine investment.
The Physical Web incorporates beacons that can be put in any small retail store, for example, so that every store now has "an app" for its customers. In this Birds-of-a-Feather session at Internet of @ThingsExpo, Scott Jenson, Product Designer at Google, will discuss the Physical Web and how it is an open standard so any device can broadcast a URL wirelessly, so any phone/tablet/watch nearby can see, and rank those devices. When the user taps on one, they just go to that web page. It's really that simple. It's about thinking small, enabling micro-information (what is in my prescription bottle...
BSQUARE is a global leader of embedded software solutions. We enable smart connected systems at the device level and beyond that millions use every day and provide actionable data solutions for the growing Internet of Things (IoT) market. We empower our world-class customers with our products, services and solutions to achieve innovation and success. For more information, visit www.bsquare.com.
Whether you're a startup or a 100 year old enterprise, the Internet of Things offers a variety of new capabilities for your business. IoT style solutions can help you get closer your customers, launch new product lines and take over an industry. Some companies are dipping their toes in, but many have already taken the plunge, all while dramatic new capabilities continue to emerge. In his session at Internet of @ThingsExpo, Reid Carlberg, Senior Director, Developer Evangelism at salesforce.com, to discuss real-world use cases, patterns and opportunities you can harness today.