Welcome!

IBM Cloud Authors: Elizabeth White, AppDynamics Blog, Liz McMillan, Jason Bloomberg, Pat Romanski

News Feed Item

Prize4Life Announces $50,000 ALS Prediction Prize Winners

Solutions Take Researchers a Step Closer to Predicting the Future for ALS Patients

CAMBRIDGE, MA -- (Marketwire) -- 11/13/12 -- Prize4Life, a nonprofit organization whose mission is to accelerate the discovery of treatments and a cure for ALS (Amyotrophic Lateral Sclerosis, also known as Lou Gehrig's disease), announced today three winners of its $50,000 DREAM-Phil Bowen ALS Prediction Prize4Life Challenge (or ALS Prediction Prize), which was run in collaboration with InnoCentive, Inc., the global leader in open innovation, crowdsourcing and prize competitions, and IBM's DREAM Project.

ALS, a fatal disease, is difficult to predict. Although the average life expectancy of an ALS patient is about three years, some people live for decades, while others succumb within months. This lack of predictability makes the design of clinical trials to discover new treatments a long, costly and complex process. The ALS Prediction Prize provided competing teams with access to anonymous ALS patient data collected in previous clinical trials. With more than 1,000 participants in the Challenge, crowdsourcing via InnoCentive's global network approach resulted in 37 potential solutions from teams and individuals around the globe.

Two teams have secured first place in the ALS Prediction Prize: a duo from Stanford University, postdoctoral candidate in mathematics and statistics Lester Mackey, PhD and recent JD and Master's Degree recipient Lilly Fang; and the team of Liuxia Wang, PhD Principal Scientist, and her colleague Guang Li, Quantitative Modeler at Washington, DC-based Scientific Marketing Company, Sentrana. Each team will receive $20,000 for generating the top-performing solutions to predict disease progression in ALS patients.

In addition, Torsten Hothorn, PhD, a distinguished statistics professor from Germany, was awarded a second-place prize of $10,000 for his unique solution, which included an alternative approach to assessing disease progression to that specified in the Challenge criteria. The Prize4Life judging panel found Hothorn's contribution to be highly valuable so they honored him with second place and a $10,000 prize.

"At the outset of the Challenge, we hoped to receive just one viable solution that would help improve the prediction of disease progression in ALS patients," said Prize4Life CEO Avi Kremer. "Not only have we seen multiple great results, but the winners come from around the world. We couldn't have been more thrilled with the results generated by all of our winning teams, which gives greater hope to those of us coping with ALS."

The ALS Prediction Prize Challenge initially sought one winner and originally allocated an award amount of $25,000, but the solutions submitted by the Stanford University team and the Sentrana team performed equally well in their predictive capabilities, leading the Prize4Life judging panel to conclude that the prize purse should be expanded.

"These winning solutions to the ALS Prediction Prize Challenge will give us important new insights into disease progression in ALS patients. Currently, ALS clinical trials must include large numbers of patients to account for the enormous variance in the course of the disease progression, which makes these trials expensive, and more difficult to interpret," said Prize4Life Chief Scientific Officer Dr. Melanie Leitner. "The solutions to the ALS Prediction Prize will have two important and immediate benefits: they will increase the likelihood of ALS clinical trial success, and our experts estimate that these algorithms can reduce the number of patients required for a clinical trial by 23 percent."

Prize winner Lester Mackey notes, "Lilly and I were eager to be part of the ongoing effort to make ALS disease prognosis more accurate and useful and we are thrilled that our solution was chosen as one of the best to contribute to the cause of defeating ALS."

The ALS Prediction Prize Challenge was based on the PRO-ACT database, which was developed in collaboration with the Northeast ALS Consortium (NEALS) and the Neurological Clinical Research Institute at Massachusetts General Hospital, and with funding from the ALS Therapy Alliance. A subset of the PRO-ACT database was made available to participants via the InnoCentive platform and the full PRO-ACT dataset will be made available to the global scientific community for research on December 5, 2012. PRO-ACT will contain clinical data from over 8,500 ALS patients from completed clinical trials, ten times more than had been available previously.

The ALS Prediction Prize is the second Challenge in which Prize4Life partnered with InnoCentive. The first was the $1 million ALS Biomarker Prize awarded in early 2011 to Dr. Seward Rutkove of Beth Israel Deaconess Medical Center in Boston for his development of a technology that accurately measures the progression of ALS in patients, thereby enabling better assessment of therapeutic effect during clinical trials.

About Prize4Life
Prize4Life is a 501(c)(3) nonprofit organization whose mission is to accelerate the discovery of treatments and a cure for ALS (Amyotrophic Lateral Sclerosis, also known as Lou Gehrig's disease) by using powerful incentives to attract new people and drive innovation. Prize4Life believes that solutions to some of the biggest challenges in ALS research will require out-of-the-box thinking, and that some of the most critical discoveries may come from unlikely places. Founded in 2006 by Avi Kremer, who was diagnosed with ALS at the age of 29, Prize4Life encourages and rewards creative approaches that will yield real results for ALS patients. For more information, visit www.prize4life.org.

About InnoCentive
InnoCentive is the global leader in crowdsourcing innovation problems to the world's smartest people who compete to provide ideas and solutions to important business, social, policy, scientific, and technical challenges. For more than a decade, leading commercial, government, and nonprofit organizations have partnered with InnoCentive to rapidly generate innovative new ideas and solve pressing problems. For more information, visit www.innocentive.com.

More Stories By Marketwired .

Copyright © 2009 Marketwired. All rights reserved. All the news releases provided by Marketwired are copyrighted. Any forms of copying other than an individual user's personal reference without express written permission is prohibited. Further distribution of these materials is strictly forbidden, including but not limited to, posting, emailing, faxing, archiving in a public database, redistributing via a computer network or in a printed form.

@ThingsExpo Stories
The IoT has the potential to create a renaissance of manufacturing in the US and elsewhere. In his session at 18th Cloud Expo, Florent Solt, CTO and chief architect of Netvibes, will discuss how the expected exponential increase in the amount of data that will be processed, transported, stored, and accessed means there will be a huge demand for smart technologies to deliver it. Florent Solt is the CTO and chief architect of Netvibes. Prior to joining Netvibes in 2007, he co-founded Rift Technol...
Join IBM June 8 at 18th Cloud Expo at the Javits Center in New York City, NY, and learn how to innovate like a startup and scale for the enterprise. You need to deliver quality applications faster and cheaper, attract and retain customers with an engaging experience across devices, and seamlessly integrate your enterprise systems. And you can't take 12 months to do it.
This is not a small hotel event. It is also not a big vendor party where politicians and entertainers are more important than real content. This is Cloud Expo, the world's longest-running conference and exhibition focused on Cloud Computing and all that it entails. If you want serious presentations and valuable insight about Cloud Computing for three straight days, then register now for Cloud Expo.
IoT device adoption is growing at staggering rates, and with it comes opportunity for developers to meet consumer demand for an ever more connected world. Wireless communication is the key part of the encompassing components of any IoT device. Wireless connectivity enhances the device utility at the expense of ease of use and deployment challenges. Since connectivity is fundamental for IoT device development, engineers must understand how to overcome the hurdles inherent in incorporating multipl...
Machine Learning helps make complex systems more efficient. By applying advanced Machine Learning techniques such as Cognitive Fingerprinting, wind project operators can utilize these tools to learn from collected data, detect regular patterns, and optimize their own operations. In his session at 18th Cloud Expo, Stuart Gillen, Director of Business Development at SparkCognition, will discuss how research has demonstrated the value of Machine Learning in delivering next generation analytics to im...
Manufacturers are embracing the Industrial Internet the same way consumers are leveraging Fitbits – to improve overall health and wellness. Both can provide consistent measurement, visibility, and suggest performance improvements customized to help reach goals. Fitbit users can view real-time data and make adjustments to increase their activity. In his session at @ThingsExpo, Mark Bernardo Professional Services Leader, Americas, at GE Digital, will discuss how leveraging the Industrial Interne...
The paradigm has shifted. A Gartner survey shows that 43% of organizations are using or plan to implement the Internet of Things in 2016. However, not just a handful of companies are still using the old-style ad-hoc trial-and-error ways, unaware of the critical barriers, paint points, traps, and hidden roadblocks. How can you become a winner? In his session at @ThingsExpo, Tony Shan will present a methodical approach to guide the holistic adoption and enablement of IoT implementations. This ov...
SYS-CON Events announced today that Stratoscale, the software company developing the next generation data center operating system, will exhibit at SYS-CON's 18th International Cloud Expo®, which will take place on June 7-9, 2016, at the Javits Center in New York City, NY. Stratoscale is revolutionizing the data center with a zero-to-cloud-in-minutes solution. With Stratoscale’s hardware-agnostic, Software Defined Data Center (SDDC) solution to store everything, run anything and scale everywhere...
Angular 2 is a complete re-write of the popular framework AngularJS. Programming in Angular 2 is greatly simplified – now it's a component-based well-performing framework. This immersive one-day workshop at 18th Cloud Expo, led by Yakov Fain, a Java Champion and a co-founder of the IT consultancy Farata Systems and the product company SuranceBay, will provide you with everything you wanted to know about Angular 2.
Digital payments using wearable devices such as smart watches, fitness trackers, and payment wristbands are an increasing area of focus for industry participants, and consumer acceptance from early trials and deployments has encouraged some of the biggest names in technology and banking to continue their push to drive growth in this nascent market. Wearable payment systems may utilize near field communication (NFC), radio frequency identification (RFID), or quick response (QR) codes and barcodes...
SYS-CON Events announced today that Men & Mice, the leading global provider of DNS, DHCP and IP address management overlay solutions, will exhibit at SYS-CON's 18th International Cloud Expo®, which will take place on June 7-9, 2016, at the Javits Center in New York City, NY. The Men & Mice Suite overlay solution is already known for its powerful application in heterogeneous operating environments, enabling enterprises to scale without fuss. Building on a solid range of diverse platform support,...
You deployed your app with the Bluemix PaaS and it's gaining some serious traction, so it's time to make some tweaks. Did you design your application in a way that it can scale in the cloud? Were you even thinking about the cloud when you built the app? If not, chances are your app is going to break. Check out this webcast to learn various techniques for designing applications that will scale successfully in Bluemix, for the confidence you need to take your apps to the next level and beyond.
The increasing popularity of the Internet of Things necessitates that our physical and cognitive relationship with wearable technology will change rapidly in the near future. This advent means logging has become a thing of the past. Before, it was on us to track our own data, but now that data is automatically available. What does this mean for mHealth and the "connected" body? In her session at @ThingsExpo, Lisa Calkins, CEO and co-founder of Amadeus Consulting, will discuss the impact of wea...
Whether your IoT service is connecting cars, homes, appliances, wearable, cameras or other devices, one question hangs in the balance – how do you actually make money from this service? The ability to turn your IoT service into profit requires the ability to create a monetization strategy that is flexible, scalable and working for you in real-time. It must be a transparent, smoothly implemented strategy that all stakeholders – from customers to the board – will be able to understand and comprehe...
SYS-CON Events announced today that Ericsson has been named “Gold Sponsor” of SYS-CON's @ThingsExpo, which will take place on June 7-9, 2016, at the Javits Center in New York, New York. Ericsson is a world leader in the rapidly changing environment of communications technology – providing equipment, software and services to enable transformation through mobility. Some 40 percent of global mobile traffic runs through networks we have supplied. More than 1 billion subscribers around the world re...
So, you bought into the current machine learning craze and went on to collect millions/billions of records from this promising new data source. Now, what do you do with them? Too often, the abundance of data quickly turns into an abundance of problems. How do you extract that "magic essence" from your data without falling into the common pitfalls? In her session at @ThingsExpo, Natalia Ponomareva, Software Engineer at Google, will provide tips on how to be successful in large scale machine lear...
SYS-CON Events announced today that Fusion, a leading provider of cloud services, will exhibit at SYS-CON's 18th International Cloud Expo®, which will take place on June 7-9, 2016, at the Javits Center in New York City, NY. Fusion, a leading provider of integrated cloud solutions to small, medium and large businesses, is the industry's single source for the cloud. Fusion's advanced, proprietary cloud service platform enables the integration of leading edge solutions in the cloud, including cloud...
There is an ever-growing explosion of new devices that are connected to the Internet using “cloud” solutions. This rapid growth is creating a massive new demand for efficient access to data. And it’s not just about connecting to that data anymore. This new demand is bringing new issues and challenges and it is important for companies to scale for the coming growth. And with that scaling comes the need for greater security, gathering and data analysis, storage, connectivity and, of course, the...
The IETF draft standard for M2M certificates is a security solution specifically designed for the demanding needs of IoT/M2M applications. In his session at @ThingsExpo, Brian Romansky, VP of Strategic Technology at TrustPoint Innovation, will explain how M2M certificates can efficiently enable confidentiality, integrity, and authenticity on highly constrained devices.
In his session at @ThingsExpo, Chris Klein, CEO and Co-founder of Rachio, will discuss next generation communities that are using IoT to create more sustainable, intelligent communities. One example is Sterling Ranch, a 10,000 home development that – with the help of Siemens – will integrate IoT technology into the community to provide residents with energy and water savings as well as intelligent security. Everything from stop lights to sprinkler systems to building infrastructures will run ef...